eCollection 2015. Pentane expired by individual rats from the various treatment groups strongly correlated (r = 0.92, p < 0.001) with the plasma vitamin E status. 1993 Report Number. 90.59% of patients returned to previous work, and 4.89% of patients had to change their work. Fatal massive peripheral zonal hepatic necrosis developed in a 47-year-old man who accidentally ingested a solution of methyl ethyl ketone peroxide (MEKP) in dimethyl phthalate. The possibility of carbon tetrachloride poisoning after ingestion of, or exposure to, chlorinated hydrocarbons and in patients presenting with hepatic or renal impairment without obvious cause should not be ignored. The patient developed multiple complications including proximal intestinal obstruction, acidosis and acute kidney injury. HHS Different trials included the use of gastric wash, milk, H2-blockers, proton pump inhibitors and antacids for decontamination and reduction of local gastric effect and systemic toxicity. [Note: A strong oxidizing agent. According to other authors, in patients with Stage IIB and III of postcorrosive injury of upper GIT, a naso-enteral tubing for nutritional support should be placed in the first 24 hours, and first small quantities of liquids should be inserted in the first 48 hours. Dis Esophagus. It is also known as methyl ethyl ketone … Gastric lavage is contraindicated as it is a highly corrosive substance. Treatment with a combination of N-acetylcysteine and haemodialysis may be a promising therapy for this severe and potentially life-threatening intoxication. Rats fed 30 IU dl-α-tocopherol acetate/kg diet significantly (p < 0.001) decreased pentane production at 20 min by 88% compared to rats fed a vitamin E- and selenium-deficient diet. Prompt treatment with acetylcysteine may minimise subsequent hepatorenal damage. It is postulated that the mechanism of toxicity of MEKP is by free radical formation that leads to lipid peroxidation and results in corrosive injury to the gastrointestinal mucosa and liver. The vitamin C pretreatment caused a doubling of pentane levels and mortality within 3 hr. ... and a coagulopathy after ingestion of an unknown volume of methyl ethyl ketone peroxide (MEKP) in dimethyl phthalate. Epub 2016 Jan 30. In this paper we present a case of a young patient who intentionally ingested MEKP. It is made by some trees and found in some fruits and vegetables in small amounts. Methyl ethyl ketone peroxide (MEKP) is an organic peroxide, a high explosive similar to acetone peroxide. The development of carcinoma at the site of stricture, although described as early as 1941, has not been frequently commented on. 73 0 obj << /Linearized 1 /O 75 /H [ 880 336 ] /L 110511 /E 19487 /N 9 /T 108933 >> endobj xref 73 23 0000000016 00000 n 0000000807 00000 n 0000001216 00000 n 0000001624 00000 n 0000002714 00000 n 0000003800 00000 n 0000004071 00000 n 0000004099 00000 n 0000004128 00000 n 0000004408 00000 n 0000006329 00000 n 0000006351 00000 n 0000007452 00000 n 0000007740 00000 n 0000007842 00000 n 0000008932 00000 n 0000009210 00000 n 0000009423 00000 n 0000010643 00000 n 0000010665 00000 n 0000019020 00000 n 0000000880 00000 n 0000001195 00000 n trailer << /Size 96 /Info 68 0 R /Root 74 0 R /Prev 108923 /ID[<0168e48a27848ca9caaea52c01427876><35543f1ce74559645ef783973866a720>] >> startxref 0 %%EOF 74 0 obj << /Pages 71 0 R /Type /Catalog /Metadata 72 0 R >> endobj 94 0 obj << /S 186 /Filter /FlateDecode /Length 95 0 R >> stream The patients were classified to groups, less or more than 10% lactate's clearance. We report a patient with poisoning due to methyl ethyl ketone peroxide who presented with corrosive esophagitis and gastritis, gastrointestinal bleeding, and developed ischemia of the bowel and necrosis of the liver and died of severe metabolic acidosis and multiorgan failure. N-acetylcysteine and hemodialysis treatment of a severe case of methyl ethyl ketone peroxide intoxication. 1990 May;9(3):197-200. doi: 10.1177/096032719000900315. Such solutions contain about 10% active oxygen. On the other hand, the health sector requires healthy and motivated practitioners and staff to achieve these goals. Methyl Ethyl Ketone Peroxide (MEKP) is a highly toxic clear liquid used as a solvent. Dilute solutions of 30 to 40% MEKP are used in industry and by hobbyists as the catalyst which initiates the crosslinking of unsaturated polyester resins used in fiberglass, and casting. Mater Sociomed. Moreover, the mean GSH levels in the same esophageal tissues were significantly lower in groups C and D than in groups A and B (P < .05). The patient was treated with the free radical scavenger N-acetylcysteine to counteract free radical-mediated damage and with hemodialysis to remove accumulated organic acids. You can request the full-text of this article directly from the authors on ResearchGate. Organizational culture plays a supportive role in modification of structure and implementation of new management systems. ... [3]. 10.6 Hazardous decomposition products. Background: MEKP is a colorless, oily liquid whereas acetone peroxide is a white powder at STP; MEKP is slightly less sensitive to shock and temperature, and more stable in storage. Knowledge of MEKP dangerousness and good work practices can prevent accidental MEKP poisoning. We report a patient with poisoning due to methyl ethyl ketone peroxide who presented with upper gastrointestinal bleeding, and developed gangrene of the bowel and died of septicaemia and multiorgan failure. It is also released to the air from car and truck exhausts. A 6-year-old boy developed respiratory distress, metabolic acidosis, severe esophageal and gastric burns, and a coagulopathy after ingestion of an unknown volume of methyl ethyl ketone peroxide (MEKP) in dimethyl phthalate. Pediatric caustic ingestion: 50 consecutive cases and a review of the literature. Besides, his cardiac and hepatic functions, and coagulapthy were rapidly improved.