MetHb < 20%: asymptomatic or have headache, fatigue, dyspnea, and lethargy (cerebral ischemia). Taking MAO inhibitors (isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) with this medication may cause a serious drug interaction. McPhee JS, Papadakis MA, eds. Interstitial cystitis/painful bladder syndrome. Black urine results from Blackwater Fever, which is associated with malaria. Normal concentration of MetHb – < 1% of total Hb ( autooxidation of Hb to MetHb occurs spontaneously at a slow rate, each day converting 0.5 to 3 % of the available Hb to MetHb. You may only need to receive one dose of methylene blue. You should probably avoid this color, if at all possible. This autooxidation, combined with the subsequent reduction of MetHb acts to maintain a steady-state level of MetHb). Clear—All it takes to achieve clear urine is to drink plenty of water. Panzera AK. Milky or Cloudy—This results from blood, protein, or pus in the urine and usually indicates illness and is not an effect you can achieve by eating or drinking something non-toxic. The product information provided in this site is intended for residents of the United States. Some of the ingredients in Uribel® can pass into breast milk and may harm a nursing baby. It can also color the whites of your eyes blue. It is typically given by injection into a vein. As far as urine colorants go, this one is considered to be reasonably safe to eat, though you should be aware some people are allergic to it. Your condition will not improve faster and the risk of side effects may increase.Tell your doctor if your condition persists or worsens. Siraphol Siricharattakul / EyeEm / Getty Images. “Development of blue urine could affect compliance,” the study authors wrote. The diagnosis is confirmed by direct measurement of methemoglobin by a multiple wavelength co-oximeter. The coloration of both urine and eyes is reversible. A very dark color might indicate the presence of bile in urine, which is symptomatic of a medical condition. Dr. Helmenstine holds a Ph.D. in biomedical sciences and is a science writer, educator, and consultant. Yellow—Yellow is the normal color of urine. Methylene blue is the first line. When > 10 % (or 1.5 g/dL absolute concentration of MetHb) – central cyanosis occurs. It has previously been used for cyanide poisoning and urinary tract infections, but this use is no longer recommended. Drinking an energy drink won't help because the caffeine acts as a diuretic, adding more water to your urine and making it colorful, but pale. Can be fatal. Specifically, it is used to treat methemoglobin levels that are greater than 30% or in which there are symptoms despite oxygen therapy. INDICATIONS: Uribel® (methenamine, sodium phosphate monobasic, phenyl salicylate, methylene blue, and hyoscyamine sulfate) is a prescription medicine used to relieve the discomfort, pain, frequent urge to urinate, and cramps/spasms of the urinary tract caused by a urinary tract infection or a diagnostic procedure. This material is intended to provide basic information and is not medical advice. Orange—Eating rhubarb or senna can turn your urine orange. Food coloring can also turn your urine green, as can certain medications. Senna is a dangerous herb to mess with. Learn how you can pay as little as $20 for Uribel. Urol Nurs. However, an abnormal value in an asymptomatic patient may suggest the presence of an elevated methemoglobin fraction. Ask your doctor when to start or stop taking these medications. Each dose is one capsule that should be taken with plenty of fluid. It is reasonable to perform serial measurements of MetHb levels following treatment with MB. Current Medical Diagnosis and Treatment. This medicine can cause your urine and sometimes your stools to turn a bluish color. Also, (and I swear this is not a joke) there is a website out there called,, (It’s official, there is now a website for everything.) prilocaine). Panzera AK. Brown urine is not a good thing. Blueberries can also tint urine pink. King George III's blue urine may have been attributable to porphyria. local anesthetics: prilocaine (with lidocaine in EMLA cream. 2. As a medication, it is mainly used to treat methemoglobinemia. It accelerates the enzymatic reduction of methemoglobin by NADPH-methemoglobin reductase and also reduces to leucomethylene blue that, in turn, reduces methemoglobin. An alternative treatment for these patients – ascorbic acid (2mg/kg). Red—Eating beets or blackberries can turn your urine red. An asymptomatic patient with a MetHb level <20 % – no therapy other than discontinuation of the offending agent. The Visible Spectrum: Wavelengths and Colors, Ph.D., Biomedical Sciences, University of Tennessee at Knoxville, B.A., Physics and Mathematics, Hastings College. If you experience a rapid pulse, dizziness, or blurred vision, discontinue use immediately. Blue—Methylene blue will turn your urine blue or greenish-blue. The most common side effects of Uribel® are rapid heartbeat, flushing, blurred vision, dizziness, drowsiness, difficulty urinating, inability to urinate, dry mouth, nausea, vomiting, shortness of breath or trouble breathing. Congenital – diminished enzymatic reduction of MetHb back to functional Hb. Hyperbaric oxygen has been used with anecdotal success in severe cases. If you do need a second dose, it can be given 1 hour after your first dose. INDICATIONS: Uribel ® (methenamine, sodium phosphate monobasic, phenyl salicylate, methylene blue, and hyoscyamine sulfate) is a prescription medicine used to relieve the discomfort, pain, frequent urge to urinate, and cramps/spasms of the urinary tract caused by a urinary tract infection or a diagnostic procedure.. What Is the Chemical Composition of Urine? MSDS – Methylene Blue. Blood transfusion or exchange transfusion may be helpful in patients who are in shock. MB provides an artificial electron transporter for the reduction of MetHb via the NADPH-dependent pathway. A pain reliever to treat pain and burning sensations when you urinate, An antispasmodic to help relax the smooth muscle tissue of your urinary tract, Adult Dosing: Take one Uribel capsule 4 times a day; however, please follow your doctor’s instructions, Older Children Dosing: Follow your doctor's individualized dosing (Not recommended for use in children 6 and under), Take each Uribel dose with ample amounts of fluid, Uribel may be used in conjunction with antibiotic therapies or other medicines, You should not take more than the recommended dose of Uribel capsules, Uribel typically causes your urine to turn blue or bluish-green and may also affect the color of your stool. You should not take more than the prescribed dose of Uribel®. Hyperbaric O2 and exchange transfusions can also be utilized. Interstitial cystitis/painful bladder syndrome. Uribel contains 5 ingredients that work together to treat your symptoms: ‡Uribel does not replace antibiotic therapy prescribed by your doctor. Call your doctor for medical advice about side effects. All medical advice, diagnosis, and treatment should be obtained from your physician. MB should not be administered to patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency, since the reduction of MetHb by MB is dependent upon NADPH generated by G6PD (hemolysis). Uribel® is not for everyone.